未行包皮环切术男性的阴茎人乳头瘤病毒感染清除率降低。
Reduced clearance of penile human papillomavirus infection in uncircumcised men.
机构信息
Cancer Research Center of Hawaii, 1236 Lauhala St, Honolulu, HI 96813, USA.
出版信息
J Infect Dis. 2010 May 1;201(9):1340-3. doi: 10.1086/651607.
Abstract
The relationship between circumcision and the acquisition and clearance of human papillomavirus (HPV) infection was examined in a cohort of 357 men followed up at 2-month intervals for an average of 431 days. There were no differences in HPV acquisition by circumcision status. Clearance of HPV infection, including infection with oncogenic types, was slower in the glans/coronal sulcus of the penis of uncircumcised men than circumcised men. The median duration of HPV infection of the glans/coronal sulcus was significantly longer in uncircumcised men (154 days) than circumcised men (91 days) (P=.04). Circumcision may protect against HPV-associated disease by enhancing the resolution of infection.
摘要
本研究对 357 名男性进行了队列研究，这些男性在平均 431 天的时间内每 2 个月接受一次随访。研究结果显示，包皮环切状态与 HPV 感染的获得无关。在未行包皮环切术的男性中，HPV 感染（包括致癌型 HPV 感染）的清除速度比行包皮环切术的男性慢。未行包皮环切术的男性阴茎龟头/冠状沟的 HPV 感染中位持续时间显著长于行包皮环切术的男性（154 天比 91 天）（P=.04）。包皮环切术可能通过增强感染的清除来预防 HPV 相关疾病。
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