Lifestyle-Related Disease Prevention Center, Shiga University of Medical Science, Otsu, Japan.
J Epidemiol. 2010;20 Suppl 3(Suppl 3):S537-43. doi: 10.2188/jea.je20090222.
It has been considered that reducing protein intake is one of important measures to delay the progression of chronic kidney disease (CKD). However, the relationship between protein intake and renal function is still uncertain, especially in relatively healthy general population.
7404 individuals (3099 men and 4305 women) who participated in both National Survey on Circulatory Disorders and National Nutrition Survey in 1990 and were free from past history of renal diseases were included in the present study. We estimated sex-specific age- and multivariate-adjusted glomerular filtration rate (GFR) and odds ratios for the presence of CKD according to the quartiles of protein (total, animal, vegetable) intake per body weight (kg).
There were significant differences in each protein intake among the age groups in both men and women. Both participants with and without CKD took more protein intake than that of each recommended level. There were positive relationships between GFR and the quartiles of each protein intake in both sexes. The odds ratios for the presence of CKD were significantly decreased in the higher quartile of protein intake in women.
The higher protein intake was associated with higher GFR in both sexes and low prevalence of CKD in women. However, further studies are needed to conclude the relationships between protein intake and renal function.
减少蛋白质摄入量被认为是延缓慢性肾脏病(CKD)进展的重要措施之一。然而,蛋白质摄入量与肾功能之间的关系仍不确定,特别是在相对健康的一般人群中。
本研究纳入了 1990 年参加全国循环系统疾病调查和全国营养调查且无肾脏疾病既往史的 7404 名个体(男性 3099 名,女性 4305 名)。我们根据蛋白质(总蛋白、动物蛋白、植物蛋白)摄入量按体重(kg)的四分位间距,估计了性别特异性年龄和多变量调整后的肾小球滤过率(GFR),并按 CKD 的存在计算了比值比。
无论男女,各年龄组的蛋白质摄入量均存在差异。有和无 CKD 的参与者的蛋白质摄入量均高于各推荐水平。在男女中,GFR 与各蛋白质摄入量的四分位间距均呈正相关。在女性中,蛋白质摄入量较高的四分位间距与 CKD 的存在呈显著负相关。
在男女中,较高的蛋白质摄入量与较高的 GFR 相关,且女性 CKD 的患病率较低。然而,需要进一步的研究来确定蛋白质摄入量与肾功能之间的关系。