Woodward K N
Veterinary Medicines Directorate, New Haw, Weybridge, Surrey, UK.
Vet Hum Toxicol. 1991 Apr;33(2):168-72.
There is a small but unquantifiable risk that residues of hypersensitivity-inducing drugs may elicit hypersensitivity reactions in human consumers of food of animal origin. The levels present are unlikely to be sufficient to cause initial sensitization, and this is most likely to occur by therapeutic use in man. However, these levels may occasionally elicit hypersensitivity reactions in previously sensitized patients. The available data suggests that the incidences of such reactions are exceedingly low and the risk can be minimised by the careful use and observance of withdrawal periods. Occupational exposure may present a higher, but again unquantifiable risk which may also be reduced by the production of low-dusting formulations, by the observance of precautionary phrases, and by the use of suitable protective clothing.
存在一种虽小但无法量化的风险，即诱发过敏的药物残留可能会在食用动物源性食品的人类消费者中引发过敏反应。目前的残留水平不太可能足以引发初次致敏，初次致敏最有可能发生在人类的治疗用药过程中。然而，这些残留水平偶尔可能会在既往已致敏的患者中引发过敏反应。现有数据表明，此类反应的发生率极低，通过谨慎使用并遵守休药期，风险可降至最低。职业暴露可能带来更高但同样无法量化的风险，通过生产低粉尘制剂、遵守预防说明以及使用合适的防护服，也可降低这一风险。
