Brayfield C, Marra K, Rubin J P
Department of Plastic Surgery, University of Pittsburgh, 3380 Boulevard of the Allies, Pittsburgh, PA 15213, USA.
Handchir Mikrochir Plast Chir. 2010 Apr;42(2):124-8. doi: 10.1055/s-0030-1248269. Epub 2010 Mar 29.
Adipose-derived stem cells (ASCs) can be isolated from human adipose tissue with the exceptional potential for differentiation into mature adipocytes. Utilization of this system is very promising in developing improved techniques to repair soft tissue defects. Current reconstructive procedures, especially after trauma and oncological surgery, transfer autologous soft tissue grafts having limitations. However, ASCs offer the ability to either generate soft tissue with no donor-site morbidity (with the exception of a minor loss of adipose tissue) or enhance the viability and durability of other grafts. This review will discuss the relevant properties of human adult adipose-derived stem cells for the regeneration of adipose tissue. Discussion will focus on the biology of ASCs, cell delivery vehicles/scaffolds useful in applying ASCs as a therapy, and suitable IN VIVO animal models for studying adipose tissue engineering. Also included is a description of the current clinical studies with ASCs in Europe and Asia.
脂肪来源干细胞（ASCs）可从人体脂肪组织中分离出来，具有分化为成熟脂肪细胞的特殊潜能。该系统在开发改进的软组织缺损修复技术方面极具前景。目前的重建手术，尤其是在创伤和肿瘤外科手术后，自体软组织移植存在局限性。然而，脂肪来源干细胞能够生成无供区并发症的软组织（除少量脂肪组织损失外），或提高其他移植物的活力和耐久性。本综述将讨论人成年脂肪来源干细胞在脂肪组织再生方面的相关特性。讨论将集中在脂肪来源干细胞的生物学特性、将脂肪来源干细胞用作治疗手段时有用的细胞递送载体/支架，以及用于研究脂肪组织工程的合适体内动物模型。还包括对欧洲和亚洲目前脂肪来源干细胞临床研究的描述。
