Li Yingying, He Zhipeng, Zhang Peigen, Gao Junshan, Cheng Chuanwei, Zhang Haiqian
College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Naniing 210016, Jiangsu, China.
J Nanosci Nanotechnol. 2010 Jan;10(1):520-4. doi: 10.1166/jnn.2010.1723.
A novel complex of beta-cyclodextrin with phenylazophenylalanine (PAP)-conjugated CdS quantum dot (Fazo-CdS QD) was fabricated for a photocontrollable toxicity study of CdS. Photocontrolling release of Fazo-CdS QDs from the complex was confirmed under UV irradiation by the steady state photoluminescence (PL) spectroscopy. The cytotoxicity of the surface modified CdS QDs was evaluated in vivo. The results suggest that the Fazo-CdS QDs conjugated with beta-CD could be almost nontoxicity, which may have great potential applications in biological labeling and imaging.
制备了一种新型的β-环糊精与苯偶氮苯丙氨酸（PAP）共轭的硫化镉量子点（Fazo-CdS QD）复合物，用于CdS的光控毒性研究。通过稳态光致发光（PL）光谱证实了在紫外光照射下，Fazo-CdS QDs从复合物中光控释放。对表面修饰的CdS QDs的细胞毒性进行了体内评估。结果表明，与β-环糊精共轭的Fazo-CdS QDs几乎无毒，这在生物标记和成像方面可能具有巨大的潜在应用。
