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使用喷墨打印对微针进行改性。

Modification of microneedles using inkjet printing.

作者信息

Boehm R D, Miller P R, Hayes S L, Monteiro-Riviere N A, Narayan R J

出版信息

AIP Adv. 2011 Jun;1(2):22139. doi: 10.1063/1.3602461. Epub 2011 Jun 10.

DOI:10.1063/1.3602461
PMID:22125759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3217292/
Abstract

In this study, biodegradable acid anhydride copolymer microneedles containing quantum dots were fabricated by means of visible light dynamic mask micro-stereolithography-micromolding and inkjet printing. Nanoindentation was performed to obtain the hardness and the Young's modulus of the biodegradable acid anhydride copolymer. Imaging of quantum dots within porcine skin was accomplished by means of multiphoton microscopy. Our results suggest that the combination of visible light dynamic mask micro-stereolithography-micromolding and inkjet printing enables fabrication of solid biodegradable microneedles with a wide range of geometries as well as a wide range of pharmacologic agent compositions.

摘要

在本研究中，通过可见光动态掩膜微立体光刻 - 微成型和喷墨打印技术制备了含有量子点的可生物降解酸酐共聚物微针。进行纳米压痕测试以获得可生物降解酸酐共聚物的硬度和杨氏模量。借助多光子显微镜完成了猪皮肤内量子点的成像。我们的结果表明，可见光动态掩膜微立体光刻 - 微成型和喷墨打印技术相结合，能够制造出具有多种几何形状以及多种药剂成分的固态可生物降解微针。

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Modification of microneedles using inkjet printing.

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[3]
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[6]
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本文引用的文献

[1]
Editorial: 40 Years of Angewandte Chemie International Edition.

Angew Chem Int Ed Engl. 2001-1-5

[2]
Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing.

Biomicrofluidics. 2011-3-30

[3]
Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles.

Faraday Discuss. 2011

[4]
Analysis of Mechanical Failure of Polymer Microneedles by Axial Force.

J Korean Phys Soc. 2010-4

[5]
High loading of gentamicin in bioadhesive PVM/MA nanostructured microparticles using compressed carbon-dioxide.

Pharm Res. 2010-12-2

[6]
Microneedle-mediated intradermal nanoparticle delivery: Potential for enhanced local administration of hydrophobic pre-formed photosensitisers.

Photodiagnosis Photodyn Ther. 2010-10-8

[7]
Two Photon Polymerization-Micromolding of Polyethylene Glycol-Gentamicin Sulfate Microneedles.

Adv Eng Mater. 2010-4

[8]
Pulsed laser deposition of antimicrobial silver coating on Ormocer microneedles.

Biofabrication. 2009-12

[9]
Quantum dot-based theranostics.

Nanoscale. 2009-10-6

[10]
Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique.

Pharm Res. 2010-5-19

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