基于伪三元相图法对中药挥发油微乳剂的研究
[Study on Chinese herbs' volatile oil micro-emulsions by means of pseudo-ternary phase diagram].
作者信息
Yang Meng-Meng, Zhang Yan, Liu Xin-You, Zhang Ting-Ting, Liu Mei
机构信息
Department of Pharmaceutics, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China.
出版信息
Zhong Yao Cai. 2011 Aug;34(8):1288-92.
OBJECTIVE
To optimize the formulation of Chinese herbs' volatile oil micro emulsion.
METHODS
Sreened the formulation of blank micro-emulsion and the formulation of micro-emulsion contained volatile oil by means of pseudo-ternary phase diagram.
RESULTS
System of isopropyl myristate, polyoxyethylene hydrogenated castor oil, absolute ethyl alcohol and water could formed the largest area of micro-emulsion. The optimal formulation of micro-emulsion contained volatile oil was: volatile oil consisted of 2.852%, isopropyl myristate 6.65%, polyoxyethylene hydrogenated castor oil 30.42%, absolute ethyl alcohol 7.605% and water 52.47%.
CONCLUSIONS
Using pseudo-ternary phase diagram to optimize the formulation of Chinese herbs' micro-emulsion is scientific and feasible. The volatile oil's solubility is also increased by made of oil-in-water type micro-emulsion and insured the stability.
目的
优化中药挥发油微乳的处方。
方法
采用伪三元相图法筛选空白微乳处方及含挥发油微乳处方。
结果
肉豆蔻酸异丙酯、聚氧乙烯氢化蓖麻油、无水乙醇和水体系能形成最大面积的微乳。含挥发油微乳的最佳处方为：挥发油占2.852%，肉豆蔻酸异丙酯占6.65%，聚氧乙烯氢化蓖麻油占30.42%，无水乙醇占7.605%，水占52.47%。
结论
采用伪三元相图法优化中药微乳处方科学可行。制成水包油型微乳可提高挥发油溶解度并保证其稳定性。
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