[采用中心复合设计-响应面法优化巴布剂基质]
[Optimization of cataplasm matrix with face-centered design-response surface method].
作者信息
Liu Shuzhi, Li Junhong, Jin Rixian, Du Maobo
机构信息
Institute of Chinese Materia Medical, China Academy of Chinese Medical Sciences, Beijing 100700, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2009 Dec;34(24):3211-3.
OBJECTIVE
To optimize the matrix formulation of cataplasm.
METHOD
Face-centered design was used in the experimental design, and response surface was produced in quadratic polynomial after data fitting in order to explore the impacts of Sodium Polyacrylate, Carbomer and the cross-linking agent on stickiness of cataplasm, optimize the prescription of the cataplasm matrix and perform the evaluation analysis.
RESULT
The multiple correlation coefficient (R2) and adjusted R2 in the fitting method using quadratic polynomial were 0.970 and 0. 952 (F = 53.953, P = 0.0001), respectively, and the model was significant different. The ratio of optimum proportion of Sodium Polyacrylate, Carbomer and the cross-linking agent in the matrix of cataplasm was determined, which was proved efficaciously.
CONCLUSION
Face-centered design-response surface method is a simple method with good prediction result for the optimization of cataplasm matrix.
目的
优化巴布剂基质配方。
方法
实验设计采用中心复合设计，数据拟合后以二次多项式生成响应面，以探讨聚丙烯酸钠、卡波姆及交联剂对巴布剂黏性的影响，优化巴布剂基质处方并进行评价分析。
结果
二次多项式拟合方法的复相关系数（R2）和调整R2分别为0.970和0.952（F = 53.953，P = 0.0001），模型差异有统计学意义。确定了巴布剂基质中聚丙烯酸钠、卡波姆及交联剂的最佳比例，经实验验证有效。
结论
中心复合设计-响应面法是优化巴布剂基质的一种简便方法，预测结果良好。
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