[采用均匀设计法优化复方跌打镇痛巴布剂基质配方]
[Optimization of the matrix formulation of compound Die Da Zhen Tong cataplasm by uniform design].
作者信息
Zhang Ji-xing, Wang Jian-ping, Zhu Feng, Deng Zi-jie, Zhao Cui-wei
机构信息
Guangdong Pharmaceutical University, Guangzhou 510006, China.
出版信息
Zhong Yao Cai. 2011 Jun;34(6):971-4.
OBJECTIVE
To optimize the matrix formulation of compound Die Da Zhen Tong cataplasm.
METHODS
The optimal preparation was selected by U17 (17(16)) uniform design, independent variables were the percentage ratio of the matrix formulation component part in compound Die Da Zhen Tong cataplasm,and the viscosity, continued viscosity and overall desirability used as indexes were dependent variables.
RESULTS
The percentage of the matrix formulation component part in compound Die Da Zhen Tong cataplasm was, NP-700: carbomer 980: PVP K-90: dihydroxy aluminum: tartaric: kaolinite: sorbitol: glycerin = 5: 1. 2: 2.5: 0.25: 0.15:4: 12: 5.
CONCLUSION
The optimized cataplasm has good viscosity, continued viscosity and high overall desirability.
目的
优化复方跌打镇痛巴布膏的基质配方。
方法
采用U17(17(16))均匀设计筛选最佳制剂，自变量为复方跌打镇痛巴布膏中基质配方各成分的百分比，以黏度、持黏力和综合评分为指标作为因变量。
结果
复方跌打镇痛巴布膏中基质配方各成分的百分比为，NP - 700∶卡波姆980∶聚乙烯吡咯烷酮K - 90∶氢氧化铝∶酒石酸∶高岭土∶山梨醇∶甘油 = 5∶1.2∶2.5∶0.25∶0.15∶4∶12∶5。
结论
优化后的巴布膏具有良好的黏度、持黏力和较高的综合评分。
Zotero 插件