基于喹啉平台的用于检测 Zn2+ 的可见及荧光传感器。

Both visual and fluorescent sensor for Zn2+ based on quinoline platform.

机构信息

Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.

出版信息

Inorg Chem. 2010 May 3;49(9):4002-7. doi: 10.1021/ic901354x.

DOI:10.1021/ic901354x

PMID:20353156

Abstract

A fluorescent Zn(2+) sensor 2-(hydroxymethyl)-4-methyl-6-((quinolinyl-8-imino)methyl)phenol (HMQP) based on the 8-aminoquinoline platform has been synthesized. This sensor displays high selectivity, sensitive fluorescence enhancement, strong binding ability, and ratiometric response to Zn(2+) in Tris-HCl (50 mM, pH 7.54), THF-H(2)O (9:1, v/v). And an obvious color change between HMQP and Zn(2+)-MQP(-) can be visually observed by the naked eye. The composition of the complex Zn(2+)-MQP(-) has been found to be 1:2 based on the fluorescence/absorption titration and further confirmed by X-ray crystallography.

摘要

基于 8-氨基喹啉平台，合成了一种荧光 Zn(2+)传感器 2-(羟甲基)-4-甲基-6-((8-喹啉基亚氨基)甲基)苯酚(HMQP)。该传感器对 Zn(2+)在 Tris-HCl(50mM，pH7.54)、THF-H(2)O(9:1，v/v)中表现出高选择性、灵敏的荧光增强、较强的结合能力和比率响应，并且 HMQP 和 Zn(2+)-MQP(-)之间可以通过肉眼观察到明显的颜色变化。通过荧光/吸收滴定法发现配合物 Zn(2+)-MQP(-)的组成为 1:2，并通过 X 射线晶体学进一步证实。