Faculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal.
Int J Radiat Biol. 2010 Apr;86(4):261-70. doi: 10.3109/09553000903564083.
Targeted radiotherapy using Auger electrons presents multiple advantages and challenges. The advantageous characteristics of this type of radiotherapy can explain the growing interest in these specific electrons for cancer therapy. During the last decade, Technetium-99m ((99m)Tc) has been used as an imaging agent and only recently has it been analysed as a potential therapeutic agent. This paper aims to be a review on the potential use of (99m)Tc as a therapeutic agent.
The physical properties of (99m)Tc along with its large availability through a generator in situ may represent a new and important pathway in targeted radiotherapy. Experimental data obtained so far has encouraged multiple researchers to investigate (99m)Tc further as a therapeutic agent for multiple common oncologic situations. In spite of these initial attempts to use (99m)Tc as a therapeutic agent beyond that of imaging, future studies are required to better define its dosimetric implications and radiobiological efficacy.
利用 Auger 电子进行靶向放射治疗具有多重优势和挑战。这种类型的放射治疗的有利特征可以解释为什么人们对这些特定电子在癌症治疗中的应用越来越感兴趣。在过去的十年中，锝-99m（Tc-99m）已被用作成像剂，直到最近才被分析为一种潜在的治疗剂。本文旨在对 Tc-99m 作为治疗剂的潜在用途进行综述。
Tc-99m 的物理特性及其通过现场发生器大量获得的特点，可能代表了靶向放射治疗的一个新的重要途径。迄今为止获得的实验数据鼓励了多名研究人员进一步研究 Tc-99m 作为治疗剂在多种常见肿瘤情况下的应用。尽管有这些最初尝试将 Tc-99m 用于治疗以外的成像目的，但仍需要进一步的研究来更好地确定其剂量学影响和放射生物学疗效。
