Mausolf Edward J, Johnstone Erik V, Mayordomo Natalia, Williams David L, Guan Eugene Yao Z, Gary Charles K
Innovative Fuel Solutions LLC, North Las Vegas, NV 89031, USA.
Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Resource Ecology, Bautzner Landstraße 400, 01328 Dresden, Germany.
Pharmaceuticals (Basel). 2021 Aug 29;14(9):875. doi: 10.3390/ph14090875.
Presented are the results of Tc and Tc production via neutron irradiation of natural isotopic molybdenum (Mo) with epithermal/resonance neutrons. Neutrons were produced using a deuterium-deuterium (D-D) neutron generator with an output of 2 × 10 n/s. The separation of Tc from an irradiated source of bulk, low-specific activity (LSA) Mo on activated carbon (AC) was demonstrated. The yields of Tc and Tc, together with their potential use in medical single-photon emission computed tomography (SPECT) procedures, have been evaluated from the perspective of commercial production, with a patient dose consisting of 740 MBq (20 mCi) of Tc. The number of neutron generators to meet the annual 40,000,000 world-wide procedures is estimated for each imaging modality: Tc versus Tc, D-D versus deuterium-tritium (D-T) neutron generator system outputs, and whether or not natural molybdenum or enriched targets are used for production. The financial implications for neutron generator production of these isotopes is also presented. The use of Tc as a diagnostic, therapeutic, and/or theranostic isotope for use in medical applications is proposed and compared to known commercial nuclear diagnostic and therapeutic isotopes.
本文展示了通过超热/共振中子对天然同位素钼（Mo）进行中子辐照产生锝（Tc）和锝的结果。使用输出为2×10ⁿ/s的氘 - 氘（D - D）中子发生器产生中子。证明了从辐照后的大量低比活度（LSA）钼源在活性炭（AC）上分离锝。从商业生产的角度评估了锝和锝的产率，以及它们在医学单光子发射计算机断层扫描（SPECT）程序中的潜在用途，患者剂量为740 MBq（20 mCi）的锝。针对每种成像模式，估计了满足全球每年40000000次程序所需的中子发生器数量：锝与锝、D - D与氘 - 氚（D - T）中子发生器系统输出，以及是否使用天然钼或富集靶材进行生产。还介绍了这些同位素的中子发生器生产的财务影响。提出了将锝用作医学应用中的诊断、治疗和/或诊疗同位素，并与已知的商业核诊断和治疗同位素进行了比较。
