Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Virology. 2010 Jun 5;401(2):137-45. doi: 10.1016/j.virol.2010.03.010. Epub 2010 Mar 30.
The recent discovery of human T-lymphotropic virus type 3 (HTLV-3) in Cameroon highlights the importance of expanded surveillance to better understand the prevalence and public health impact of this new retrovirus. HTLV diversity was investigated in 408 persons in rural Cameroon who reported simian exposures. Plasma from 29 persons (7.2%) had reactive serology. HTLV tax sequences were detected in 3 persons. Phylogenetic analysis confirmed HTLV-1 infection in two individuals and HTLV-3 infection in a third person (Cam2013AB). The complete proviral genome from Cam2013AB shared 98% identity and clustered tightly in distinct lineage with simian T-lymphotropic virus type 3 (STLV-3) subtype D recently identified in two guenon monkeys near this person's village. These results document a fourth HTLV-3 infection with a new and highly divergent strain we designate HTLV-3 (Cam2013AB) subtype D demonstrating the existence of a broad HTLV-3 diversity likely originating from multiple zoonotic transmissions of divergent STLV-3.
近期在喀麦隆发现人类 T 淋巴细胞嗜病毒 3 型（HTLV-3），突显扩大监测的重要性，以更好地了解这种新逆转录病毒的流行情况和对公共健康的影响。在喀麦隆农村报告过接触过灵长类动物的 408 人中调查了 HTLV 多样性。29 人的（7.2%）血浆出现了反应性血清学。在 3 人身上检测到 HTLV 税序列。系统进化分析证实 2 人感染 HTLV-1，第 3 人（Cam2013AB）感染 HTLV-3。来自 Cam2013AB 的完整前病毒基因组与最近在该人村庄附近的两只长尾猴中发现的灵长类 T 淋巴细胞嗜病毒 3 型（STLV-3）亚型 D 具有 98%的同一性，并紧密聚类在独特的谱系中。这些结果记录了第四例 HTLV-3 感染，是一种新的高度分化株，我们将其指定为 HTLV-3（Cam2013AB）亚型 D，表明存在广泛的 HTLV-3 多样性，可能起源于多种不同的 STLV-3 人畜共患病传播。
