Metabiota Inc., San Francisco, California, United States of America.
Yale University, New Haven, Connecticut, United States of America.
PLoS One. 2018 Apr 3;13(4):e0194647. doi: 10.1371/journal.pone.0194647. eCollection 2018.
We report on a study conducted in Guangdong Province, China, to characterize behaviors and perceptions associated with transmission of pathogens with pandemic potential in highly exposed human populations at the animal-human interface. A risk factor/exposure survey was administered to individuals with high levels of exposure to wildlife. Serological testing was performed to evaluate prior infection with several wildlife viral pathogens. Follow up serology was performed on a subset of the cohort as well as close contacts of individuals. 1,312 individuals were enrolled in the study. Contact with a wide range of wildlife species was reported in both occupational and occasional contexts. The overall proportion of individuals seropositive to any of the tested wildlife pathogens was approximately 4.0%. However, persons employed as butchers demonstrated a seropositivity of 9.0% to at least one pathogen of interest. By contrast, individuals working as hunters had lower rates of seropositivity. Among the study population, a number of other behaviors showed correlation with seropositivity, including contact with particular wildlife species such as field rats. These results demonstrate the need to further explore zoonotic risks of particular activities regarding wildlife contact, and to better understand risks of persons working as butchers with wildlife species.
我们报告了一项在中国广东省进行的研究，旨在描述在人与动物接触界面高度暴露于具有大流行潜力的病原体的人群中与病原体传播相关的行为和认知。对高暴露于野生动物的个体进行了风险因素/暴露调查。进行了血清学检测，以评估先前感染的几种野生动物病毒病原体。对队列的一部分以及个体的密切接触者进行了后续血清学检测。共纳入 1312 名研究对象。在职业和偶尔接触的情况下均报告了与多种野生动物物种的接触。总体而言，约有 4.0%的个体对任何一种检测到的野生动物病原体呈血清阳性。但是，从事屠夫职业的个体对至少一种感兴趣的病原体的血清阳性率为 9.0%。相比之下，从事猎人职业的个体的血清阳性率较低。在研究人群中，许多其他行为与血清阳性率相关，包括与特定野生动物物种（如野鼠）的接触。这些结果表明需要进一步探索与野生动物接触有关的特定活动的人畜共患病风险，并更好地了解从事与野生动物接触的屠夫的风险。
