NF-κB 加剧肺癌的发生。
NF-kappaB fans the flames of lung carcinogenesis.
机构信息
Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
出版信息
Cancer Prev Res (Phila). 2010 Apr;3(4):403-5. doi: 10.1158/1940-6207.CAPR-10-0042. Epub 2010 Mar 30.
Abstract
This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-kappaB and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating protumorigenic roles of NF-kappaB activation in lung cancer pathogenesis. Our growing understanding of the tumor-promoting NF-kappaB downstream effector pathways could lead to the development of novel approaches for lung cancer therapy and chemoprevention.
摘要
这篇关于 Deng 等人的观点（本期杂志第 424 页开始）探讨了 NF-κB 与肺癌发生之间的联系。肺癌基因工程小鼠模型的实验阐明了 NF-κB 激活在肺癌发病机制中的促肿瘤作用。我们对促进肿瘤的 NF-κB 下游效应途径的理解不断加深，可能会为肺癌治疗和化学预防带来新的方法。
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