Colombatti A, De Rossi A, Taylor B A, Chieco-Bianchi L, Meier H
Int J Cancer. 1978 Feb 15;21(2):179-85. doi: 10.1002/ijc.2910210209.
We have examined the induction of Moloney-MSV tumors in AKR and other mouse strains in relation to endogenous virus expression. All virus-free strains so far tested were tumor-susceptible, while AKR was resistant. The selectivity of MSV tumor resistance, characteristic of AKR mice, was associated with AKR virogens segregation in first backcross to MuLV-negative/MSV-susceptible mice, and in a few second backcross families. Stronger evidence that AKR ecotropic virogene expression is the major, but not the sole, determinant of M-MSV tumor resistance in AKR mice was obtained in strains partially congeneic for akv-2 viral gene and in recombinant inbred lines derived from an original cross between AKR and C57L mice. These mice or lines, in which inheritance of endogenous viral genes had occurred, at the same time inherited the ability to show strong resistance to tumor induction by an exogenous oncogenic virus. This finding suggests that ecotropic endogenous viruses can exert a beneficial effect in their hosts providing some protective functions. Although the association between AKR-MuLV and M-MSV resistance is definite, the mechanisms by which MuLV+ mice are refractory to M-MSV tumors have still to be elucidated.
我们研究了莫洛尼氏小鼠肉瘤病毒（Moloney-MSV）在AKR及其他小鼠品系中诱发肿瘤与内源性病毒表达的关系。迄今为止所检测的所有无病毒品系均对肿瘤敏感，而AKR则具有抗性。AKR小鼠所特有的MSV肿瘤抗性的选择性，与在首次回交至莫洛尼氏白血病病毒（MuLV）阴性/MSV敏感小鼠以及少数第二代回交家族中AKR病毒原的分离有关。在部分同源的akv-2病毒基因品系以及源自AKR和C57L小鼠原始杂交的重组近交系中，获得了更强的证据，表明AKR嗜亲性病毒原的表达是AKR小鼠对M-MSV肿瘤产生抗性的主要但非唯一决定因素。这些小鼠或品系在发生内源性病毒基因遗传的同时，也继承了对外源致癌病毒诱发肿瘤表现出强烈抗性的能力。这一发现表明，嗜亲性内源性病毒可以在其宿主中发挥有益作用，提供一些保护功能。尽管AKR-MuLV与M-MSV抗性之间的关联是明确的，但MuLV阳性小鼠对M-MSV肿瘤具有抗性的机制仍有待阐明。
