Colombatti A, Collavo D, Biasi G, Chieco-Bianchi L
Int J Cancer. 1975 Sep 15;16(3):427-34. doi: 10.1002/ijc.2910160309.
Infection of Moloney mouse sarcoma virus (M-MSV) in adult mice of several inbred strains revealed that all strains except AKR are highly susceptible to M-MSV tumor development. F1 hybrids between AKR and CBA, DBA/2 or NIH mice are as resistant (93%) as the parental AKR strain, which indicates that resistance is transmitted as a dominant character. First backcross mice to the susceptible parent show a 3:1 ratio of resistant to susceptible mice. This is the expected ratio for two segregating loci which independently confer resistance. The incidence of resistant F2 mice is somewhat lower than expected. Further support for the two-gene hypothesis was obtained in second backcross mice. None of the major genes affecting MuLV infection (Fv-2 and H-2) seems to play any role in this system and no linkage was found with Thy. 1 and albino, dilute, agouti and brown markers.
对几种近交系成年小鼠感染莫洛尼氏小鼠肉瘤病毒（M-MSV）的研究表明，除AKR外的所有品系对M-MSV肿瘤发生都高度敏感。AKR与CBA、DBA/2或NIH小鼠的F1杂种与亲代AKR品系一样具有抗性（93%），这表明抗性作为显性性状传递。首次回交至易感亲本的小鼠显示出抗性小鼠与易感小鼠的比例为3:1。这是两个独立赋予抗性的分离基因座的预期比例。抗性F2小鼠的发生率略低于预期。在第二次回交小鼠中获得了对双基因假说的进一步支持。影响MuLV感染的主要基因（Fv-2和H-2）似乎在该系统中不起任何作用，并且未发现与Thy.1以及白化、稀释、刺鼠和棕色标记存在连锁关系。
