Suppr超能文献

中国是否存在载脂蛋白 E4 等位基因的地理梯度?多个中国人群的系统比较。

Does the geographical gradient of ApoE4 allele exist in China? A systemic comparison among multiple Chinese populations.

机构信息

Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, No. 218 Ji-Xi Road, Hefei, 230022, People's Republic of China.

出版信息

Mol Biol Rep. 2011 Jan;38(1):489-94. doi: 10.1007/s11033-010-0132-0. Epub 2010 Mar 31.

Abstract

The allelic frequencies of apolipoprotein E (apoE) vary substantially around the world. There is a conspicuous south-to-north gradient of e4 frequencies in Europe, with the proportion of e4 carriers from only 10-15% in the south to 40-50% in the north. The mechanism may be related to the possibility that e4 carriers are less likely to develop vitamin D deficiency. In addition, Asian populations traditionally have lower e4 frequency than Europeans, which may be attributed in part to the scarce or irregular food supplies in Western world in the recent past. However, whether these geographical distribution gradients exist in China is yet unknown. ApoE genotypes of 200 children from Nanning City were determined by PCR-restriction fragment length polymorphism (RFLP) analysis. Allele frequency data of 18 other populations were collected from published sources and correlated with latitude and longitude information from different geographic resources. In our subjects, the frequencies of apoE genotypes were E3/E3: 73.0%, E3/E2: 15.0%, E4/E3: 5.0%, E4/E4: 5.0%, and E4/E2: 2.0%; the frequencies of apoE alleles were e2: 8.5%, e3: 83.0%, and e4: 8.5%, respectively. The total sample consisted of 3,679 individuals from 19 Chinese populations; the allelic frequencies were e2: 7.6%, e3: 85.5%, and e4: 6.9%, respectively; the proportion of e4 carriers was from 4.9% in Kunming to 17.5% in Harbin. Systemic comparison among multiple Chinese populations revealed that positive correlation existed between the e4 allele frequency distribution and latitude north (r=0.586, P=0.008), but no correlation of the e4 allele frequency distribution with longitude east was found (r=-0.018, P=0.942). We conclude that there is a south-to-north, but not an east-to-west gradient for the apoE4 allele in China.

摘要

载脂蛋白 E(apoE)的等位基因频率在世界各地差异很大。在欧洲,apoE 等位基因 e4 的频率存在明显的从南到北的梯度,从南部的 10-15%到北部的 40-50%。其机制可能与 e4 携带者不太可能患维生素 D 缺乏症有关。此外,亚洲人群传统上apoE 等位基因 e4 的频率低于欧洲人,这部分可能归因于过去西方世界食物供应稀缺或不规律。然而,这些地理分布梯度在中国是否存在尚不清楚。通过 PCR-限制性片段长度多态性(RFLP)分析,对南宁市 200 名儿童的 apoE 基因型进行了测定。从已发表的来源收集了 18 个其他人群的等位基因频率数据,并与来自不同地理资源的纬度和经度信息相关联。在我们的研究对象中,apoE 基因型的频率为 E3/E3:73.0%,E3/E2:15.0%,E4/E3:5.0%,E4/E4:5.0%和 E4/E2:2.0%;apoE 等位基因的频率为 e2:8.5%,e3:83.0%和 e4:8.5%。总样本由来自 19 个中国人群的 3679 个人组成;等位基因频率分别为 e2:7.6%,e3:85.5%和 e4:6.9%;e4 携带者的比例从昆明的 4.9%到哈尔滨的 17.5%不等。对多个中国人群进行系统比较发现,e4 等位基因频率分布与北纬之间存在正相关(r=0.586,P=0.008),但与东经之间没有相关性(r=-0.018,P=0.942)。我们得出结论,在中国,apoE4 等位基因存在从南到北的梯度,但不存在从东到西的梯度。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验