Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Semin Respir Crit Care Med. 2010 Apr;31(2):161-71. doi: 10.1055/s-0030-1249111. Epub 2010 Mar 30.
Primary graft dysfunction (PGD) is a form of early lung graft dysfunction that is a major cause of early morbidity and mortality following lung transplantation. Survivors of PGD have decreased long-term lung function and an increased risk of developing bronchiolitis obliterans syndrome (BOS), a manifestation of chronic graft dysfunction. This article reviews the current definition, contributing factors, and guidelines for grading clinical PGD, as well as controversies surrounding them. The current literature examining clinical risk factors for PGD is summarized, as are studies exploring molecular and biochemical markers for PGD prediction and severity. Studies examining the short- and long-term effects of PGD on lung transplant outcomes are reviewed. Lastly, we highlight the emerging concepts in lung transplantation that will potentially impact PGD incidence and outcomes.
原发性移植物功能障碍（PGD）是一种早期肺移植物功能障碍，是肺移植后早期发病率和死亡率的主要原因。PGD 幸存者的长期肺功能下降，发生闭塞性细支气管炎综合征（BOS）的风险增加，BOS 是慢性移植物功能障碍的表现。本文综述了 PGD 的当前定义、相关因素和临床分级指南，以及围绕这些指南的争议。本文还总结了目前研究 PGD 临床危险因素的文献，以及探索 PGD 预测和严重程度的分子和生化标志物的研究。本文还回顾了研究 PGD 对肺移植结果的短期和长期影响的研究。最后，我们强调了潜在影响 PGD 发生率和结果的肺移植领域的新兴概念。
