Department of Oncologic Imaging, National Cancer Centre, Singapore 169610, Singapore.
World J Gastroenterol. 2010 Apr 7;16(13):1598-609. doi: 10.3748/wjg.v16.i13.1598.
Perfusion magnetic resonance imaging (MRI) studies quantify the microcirculatory status of liver parenchyma and liver lesions, and can be used for the detection of liver metastases, assessing the effectiveness of anti-angiogenic therapy, evaluating tumor viability after anti-cancer therapy or ablation, and diagnosis of liver cirrhosis and its severity. In this review, we discuss the basic concepts of perfusion MRI using tracer kinetic modeling, the common kinetic models applied for analyses, the MR scanning techniques, methods of data processing, and evidence that supports its use from published clinical and research studies. Technical standardization and further studies will help to establish and validate perfusion MRI as a clinical imaging modality.
灌注磁共振成像（MRI）研究定量评估肝实质和肝病变的微循环状态，可用于检测肝转移瘤、评估抗血管生成治疗的效果、评估抗癌治疗或消融后的肿瘤活性，以及诊断肝硬化及其严重程度。在这篇综述中，我们讨论了基于示踪剂动力学模型的灌注 MRI 的基本概念、应用于分析的常见动力学模型、MR 扫描技术、数据处理方法以及来自已发表的临床和研究研究的支持其应用的证据。技术标准化和进一步的研究将有助于将灌注 MRI 确立为一种临床成像方式。
