Departement de Chimie, Universite de Montreal, C.P. 6128, Succ. Centre-ville, Montreal, Quebec H3C3J7, Canada.
ACS Appl Mater Interfaces. 2009 Apr;1(4):824-32. doi: 10.1021/am8002395.
We have prepared multifunctional methacrylate derivatives of bile acids as cross-linkable monomers for use in dental composites. By modifying the chemical structure of the monomers, we were able to vary the viscosity, hydrophobicity, and reactivity and have studied the effect of these parameters on the conversion of the monomers, the shrinkage during polymerization, and the mechanical properties of the resulting polymers and composites. Materials containing these new monomers generally had physical, thermal, and mechanical properties comparable to those containing the commonly used dental monomers BisGMA or UDMA and had lower polymerization shrinkage. The multimethacrylate derivatives of cholic acid, which are known to be less cytotoxic than BisGMA and UDMA, are shown to be promising materials for dental applications.
我们已将胆酸的多功能甲基丙烯酸酯衍生物制备为可交联的单体，用于牙科复合材料。通过改变单体的化学结构，我们能够改变其粘度、疏水性和反应性，并研究了这些参数对单体转化率、聚合收缩以及所得聚合物和复合材料的机械性能的影响。含有这些新型单体的材料通常具有与常用牙科单体 BisGMA 或 UDMA 相当的物理、热和机械性能，且聚合收缩率更低。已知比 BisGMA 和 UDMA 细胞毒性更低的胆酸的多甲基丙烯酸酯衍生物，是一种有前途的牙科应用材料。
