接种疫苗后，HIV 感染者乙型肝炎病毒特异性记忆 B 细胞生成受损。
Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination.
机构信息
Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, United States.
出版信息
Vaccine. 2010 May 7;28(21):3672-8. doi: 10.1016/j.vaccine.2010.03.022. Epub 2010 Mar 28.
Abstract
Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.
摘要
检测了 15 名未感染 HIV 的青少年和 12 名感染 HIV 的青少年接种乙肝疫苗后乙肝特异性记忆 B 细胞（HSMBC）的频率。与未感染 HIV 的个体相比，感染 HIV 的个体中 HSMBC 的检测频率明显较低。研究第 28 周时 HBsAb >10mIU/ml 的检测结果与 HSMBC 的检测结果密切相关，并且观察到 HBsAb 滴度与 HSMBC 频率之间存在直接相关性。在未感染 HIV 的个体中，抗体滴度 >1000mIU/ml 与更高的 HSMC 频率相关。与无病毒血症 HIV 感染者或未感染 HIV 的个体相比，病毒血症 HIV 感染者的 HSMBC 频率较低，记忆 B 细胞（MBC）增殖减少，B 细胞表型改变。
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