Department of Neurology, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan 701, Taiwan.
J Clin Neurosci. 2010 Jun;17(6):722-6. doi: 10.1016/j.jocn.2009.10.003. Epub 2010 Mar 30.
The main goals of this study were to investigate the effect of age on thermal and thermal pain thresholds and reaction time, and to analyze the influence of age-related changes in reaction time on thermal and thermal pain thresholds. Thermal thresholds (warm/cold) and thermal pain thresholds (hot/cold) were evaluated by the method of limits. Visual reaction time was evaluated in a similar way by a customized computer program. In total, 274 normal subjects (23-87 years old) were recruited. Thermal thresholds, thermal pain thresholds, and reaction time were all related to age. While warm and cold thresholds and cold pain thresholds increased with age, hot pain thresholds decreased with age. The age-related change in reaction time was insufficient to explain the age-related changes in thermal and thermal pain thresholds. In conclusion, age affects thermal and thermal pain thresholds independently of reaction time.
本研究的主要目的是探讨年龄对热觉和热痛阈值及反应时的影响，并分析年龄相关的反应时变化对热觉和热痛阈值的影响。通过极限法评估热阈值（温/冷）和热痛阈值（热/冷）。视觉反应时通过定制的计算机程序以类似的方式进行评估。共招募了 274 名正常受试者（23-87 岁）。热觉阈值、热痛阈值和反应时均与年龄有关。温觉和冷觉阈值以及冷痛阈值随年龄增长而升高，而热痛阈值随年龄增长而降低。反应时的年龄相关变化不足以解释热觉和热痛阈值的年龄相关变化。总之，年龄独立于反应时影响热觉和热痛阈值。
