Department of Medicine-Endocrinology, Kuwait University, and Department of Surgery, Mubarak Al-Kabeer Hospital, Ministry of Health, Kuwait.
Med Princ Pract. 2010;19(3):192-5. doi: 10.1159/000273071. Epub 2010 Mar 29.
To determine whether or not elevated titers of antinuclear antibodies (ANA) and/or rheumatoid factor (RF) are associated with patients with advanced peripheral arterial disease (PAD).
A cross-sectional study was done between September 2005 and December 2006. Fifty-eight patients with clinical and angiographic evidence of PAD and 41 controls were studied. Controls had no documented history of peripheral, coronary or cerebral vascular disease. All subjects were screened for metabolic syndrome and C-reactive protein (CRP) as risk factors for peripheral vascular disease. Additionally, all were tested for anti-mitochondrial, anti-neutrophil cytoplasmic and anti-smooth muscle antibodies; those with positive results were excluded. ANA and RF were measured in sera from cases and controls.
One case and 3 controls had positive anti-smooth muscle antibodies and were therefore excluded from statistical analysis. Metabolic syndrome was significantly more prevalent in patients than controls (p<0.05). Mean CRP level was 4.78+/-7.70 and 2.65+/-3.86 mg/dl in cases and controls, respectively (p=0.021). ANA were detected at a titer of >or=1:40 in 6 (10.5%) of the advanced PAD patients but none of the controls; the difference was not statistically significant. RF was less prevalent in cases than controls (p<0.05).
RF and ANA do not appear to be associated with PAD in a Kuwaiti population.
确定抗核抗体（ANA）和/或类风湿因子（RF）滴度升高是否与晚期外周动脉疾病（PAD）患者有关。
这是一项在 2005 年 9 月至 2006 年 12 月间进行的横断面研究。研究对象为 58 例具有临床和血管造影证据的 PAD 患者和 41 例对照者。对照者没有外周、冠状动脉或脑血管疾病的记录病史。所有受试者均筛查代谢综合征和 C 反应蛋白（CRP）作为外周血管疾病的危险因素。此外，所有受试者均检测抗线粒体、抗中性粒细胞胞质和抗平滑肌抗体；结果阳性者排除在外。从病例和对照者的血清中检测 ANA 和 RF。
1 例病例和 3 例对照者的抗平滑肌抗体阳性，因此被排除在统计分析之外。代谢综合征在病例中比对照者更为常见（p<0.05）。病例和对照者的平均 CRP 水平分别为 4.78+/-7.70 和 2.65+/-3.86mg/dl（p=0.021）。在 6 例（10.5%）晚期 PAD 患者中检测到 ANA 滴度>或=1:40，但在对照组中没有检测到；差异无统计学意义。RF 在病例中比对照者更为少见（p<0.05）。
RF 和 ANA 似乎与科威特人群的 PAD 无关。
