Alizade Elnur, Avcı Anıl, Açar Göksel, Fidan Serdar, Öcal Lütfi, Bulut Mustafa, Tellice Muhammed, Akçakoyun Mustafa, Pala Selçuk, Esen Ali Metin
Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey.
Postepy Kardiol Interwencyjnej. 2015;11(1):26-31. doi: 10.5114/pwki.2015.49181. Epub 2015 Mar 6.
The relation between serum rheumatoid factor levels and the extent, severity, and complexity of coronary artery disease has not been adequately studied.
Therefore, we assessed the relationship between the severity of coronary artery disease assessed by SYNTAX score and serum rheumatoid factor levels in patients with stable coronary artery disease.
We enrolled 268 consecutive patients who underwent coronary angiography. Patients with acute coronary syndrome and chronic immune disorders were excluded. Baseline serum rheumatoid factor levels were measured and the SYNTAX score was calculated from the study population.
Patients were divided into two groups. Group 1 was defined as low SYNTAX score < 22, and group 2 was defined as intermediate and high SYNTAX score > 22. Serum rheumatoid factor levels were significantly higher in the intermediate and high-SYNTAX score group than in the low-SYNTAX score group (16.4 ±9 IU/mlvs. 11.36 ±5 IU/ml, p < 0.001). Also, there was a significant correlation between rheumatoid factor and CRP levels with the SYNTAX score r = 0.411; p < 0.001 and r = 0.275; p < 0.001, respectively. On multivariate linear regression analysis, rheumatoid factor (β = 0.101, p < 0.001) was an independent risk factor for intermediate and high SYNTAX score in patients with stable coronary artery disease. In receiver operator characteristic curve analysis, optimal cut-off value of rheumatoid factor to predict high SYNTAX score was found to be 10.5 IU/ml, with 69% sensitivity and 61% specificity.
The rheumatoid factor level was independently associated with the extent, complexity, and severity of coronary artery disease assessed by SYNTAX score in patients with stable coronary artery diseases.
血清类风湿因子水平与冠状动脉疾病的范围、严重程度及复杂性之间的关系尚未得到充分研究。
因此，我们评估了采用SYNTAX评分评估的冠状动脉疾病严重程度与稳定型冠状动脉疾病患者血清类风湿因子水平之间的关系。
我们纳入了268例连续接受冠状动脉造影的患者。排除急性冠状动脉综合征和慢性免疫紊乱患者。测量基线血清类风湿因子水平，并计算研究人群的SYNTAX评分。
患者分为两组。第1组定义为SYNTAX评分低<22分，第2组定义为SYNTAX评分中高>22分。SYNTAX评分中高组的血清类风湿因子水平显著高于SYNTAX评分低组（16.4±9 IU/ml对11.36±5 IU/ml，p<0.001）。此外，类风湿因子和CRP水平与SYNTAX评分之间存在显著相关性，r分别为0.411；p<0.001和r为0.275；p<0.001。多因素线性回归分析显示，类风湿因子（β=0.101，p<0.001）是稳定型冠状动脉疾病患者SYNTAX评分中高的独立危险因素。在受试者工作特征曲线分析中，预测高SYNTAX评分的类风湿因子最佳截断值为10.5 IU/ml，敏感性为69%，特异性为61%。
在稳定型冠状动脉疾病患者中，类风湿因子水平与采用SYNTAX评分评估的冠状动脉疾病的范围、复杂性及严重程度独立相关。
