Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial.

作者信息

Brentjens Renier, Yeh Raymond, Bernal Yvette, Riviere Isabelle, Sadelain Michel

出版信息

Mol Ther. 2010 Apr;18(4):666-8. doi: 10.1038/mt.2010.31.

DOI:10.1038/mt.2010.31

PMID:20357779

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2862525/

Abstract

摘要

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本文引用的文献

[1]

The promise and potential pitfalls of chimeric antigen receptors.

Curr Opin Immunol. 2009-4

[2]

Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy.

J Immunother. 2009

[3]

Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts.

Clin Cancer Res. 2007-9-15

[4]

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15.

Nat Med. 2003-3

[5]

Targeting tumours with genetically enhanced T lymphocytes.

Nat Rev Cancer. 2003-1

[6]

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor.

Nat Biotechnol. 2002-1

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Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial.

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