Departamento de Análises Clínicas e Toxicológicas, CCS, Universidade Federal de Santa Maria, Santa Maria RS, Brazil.
Oxid Med Cell Longev. 2009 Apr-Jun;2(2):82-7. doi: 10.4161/oxim.2.2.8355.
Successful hematopoietic stem cell transplantation (HSCT), both autologous and allogeneic, requires a rapid and durable engraftment, with neutrophil (>500/microL) and platelet (>20,000/microL) reconstitution. Factors influencing engraftment after autologous or allogeneic HSCT were investigated in 65 patients: 25 autologous peripheral stem cell transplantation (PBSCT) and 40 allogeneic bone marrow transplantation (BMT) patients. The major factor affecting engraftment was the graft source for HSCT. Neutrophil and platelet recovery were more rapid in autologous PBSCT than in allogeneic BMT [neutrophil occurring in median on day 10.00 (09.00/11.00) and 19.00 (16.00/23.00) and platelet on day 11.00 (10.00/13.00) and 21.00 (18.00/25.00), respectively; p < 0.0001]. The type of disease also affected engraftment, where multiple myeloma (MM) and lymphoma showed faster engraftment when compared with leukemia, syndrome myelodysplastic (SMD) and aplastic anemia (AA) and MM presented the best overall survival (OS) in a period of 12 months. Other factors included the drug used in the conditioning regimen (CR), where CBV, melphalan (M-200) and FluCy showed faster engraftment and M-200 presented the best OS, in a period of 12 months and age, where 50-59 years demonstrated faster engraftment. Sex did not influence neutrophil and platelet recovery.
成功的造血干细胞移植（HSCT），无论是自体还是异体，都需要快速和持久的植入，中性粒细胞（>500/μL）和血小板（>20,000/μL）的重建。本研究旨在探讨影响自体和异体 HSCT 后植入的因素。65 例患者接受了研究：25 例自体外周造血干细胞移植（PBSCT）和 40 例异基因骨髓移植（BMT）患者。影响植入的主要因素是 HSCT 的移植物来源。自体 PBSCT 中性粒细胞和血小板恢复较异体 BMT 更快[中性粒细胞中位数分别在第 10 天（9.00/11.00）和第 19 天（16.00/23.00），血小板中位数分别在第 11 天（10.00/13.00）和第 21 天（18.00/25.00）恢复；p<0.0001]。疾病类型也影响植入，多发性骨髓瘤（MM）和淋巴瘤与白血病、骨髓增生异常综合征（SMD）和再生障碍性贫血（AA）相比，植入更快，MM 在 12 个月时总生存（OS）最佳。其他因素包括预处理方案（CR）中使用的药物，CBV、美法仑（M-200）和氟达拉滨（FluCy）的植入更快，M-200 在 12 个月时 OS 最佳，年龄方面，50-59 岁植入更快。性别对中性粒细胞和血小板的恢复没有影响。
