关于影响造血干细胞移植主要结局的因素的简要综述。
A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes.
作者信息
Rafiee Mohammad, Abbasi Mohammad, Rafieemehr Hassan, Mirzaeian Amin, Barzegar Mohieddin, Amiri Vahid, Shahsavan Shaghayegh, Mohammadi Mohammad Hossein
机构信息
Department of Hematology and Blood Banking School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences Tehran Iran.
Department of Medical Laboratory Sciences School of Paramedicine, Hamadan University of Medical Sciences Hamadan Iran.
出版信息
Health Sci Rep. 2021 May 7;4(2):e282. doi: 10.1002/hsr2.282. eCollection 2021 Jun.
BACKGROUND AND AIMS
As a curative procedure, hematopoietic stemcell transplantation (HSCT) is an approved treatment for many malignant orbenign hematologic and non-hematologic diseases. There are different outcomes of HSCT, as well as several parameters influencing these outcomes.
METHODS
We had searched scientific sources like Web ofScience and PubMed with a combination of keywords such as HSCT, engraftment,survival, outcomes, etc. Totally, 80 articles were included.
RESULTS
Here we have reviewed the effective factors onmain outcomes of HSCT including engraftment, survival, graft versus hostdisease, and Mobilization. Also, the prediction of hematological reconstitutionand some novel suggestions leading to better outcomes are reviewed.
CONCLUSION
The study will be applicable for improvedmanagement of autologous and allogeneic HSCT process to increase the procedureefficiency.
背景与目的
作为一种治疗手段，造血干细胞移植（HSCT）是许多恶性或良性血液系统及非血液系统疾病的一种获批治疗方法。HSCT有不同的结果，同时也有几个影响这些结果的参数。
方法
我们使用HSCT、植入、生存、结果等关键词组合在科学资源库如科学网和PubMed上进行搜索。总共纳入了80篇文章。
结果
在此我们回顾了影响HSCT主要结果的相关因素，包括植入、生存、移植物抗宿主病和动员。此外，还回顾了血液学重建的预测以及一些能带来更好结果的新建议。
结论
该研究将适用于改进自体和异基因HSCT过程的管理，以提高手术效率。
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