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铁毒性:新情况不断出现。

Iron toxicity: new conditions continue to emerge.

机构信息

Department of Biology and Program in Medical Sciences, Indiana University, Bloomington, IN 47405, USA.

出版信息

Oxid Med Cell Longev. 2009 Apr-Jun;2(2):107-9. doi: 10.4161/oxim.2.2.8162.

Abstract

During the past half century, excessive/misplaced iron has been observed to be a risk factor for an increasing number and diversity of disease conditions. An extensive list of conditions and of the types of iron association were published in early 2008. Within the subsequent year, four additional disorders have been recognized to be enhanced by iron: aging muscle atrophy, viral replication, rosacea and pulmonary alveolar proteinosis. This paper adds new data and emphasis on these disorders as entities associated with increased iron load and toxicity.

摘要

在过去的半个世纪中,过量/错位的铁已被观察到是越来越多和多样化的疾病状况的一个风险因素。大量的疾病状况和铁关联类型在 2008 年初被发表。在随后的一年中,又有四种疾病被认为因铁的作用而加重:衰老性肌肉萎缩、病毒复制、酒渣鼻和肺泡蛋白沉积症。本文为这些疾病添加了新的数据和重点,这些疾病是与铁负荷和毒性增加相关的实体。

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Iron toxicity: new conditions continue to emerge.铁毒性:新情况不断出现。
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本文引用的文献

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Disruption of iron homeostasis and lung disease.铁稳态失衡与肺部疾病
Biochim Biophys Acta. 2009 Jul;1790(7):731-9. doi: 10.1016/j.bbagen.2008.11.004. Epub 2008 Dec 3.
2
Oxidative stress and ferritin expression in the skin of patients with rosacea.酒渣鼻患者皮肤中的氧化应激与铁蛋白表达
J Am Acad Dermatol. 2009 Feb;60(2):270-6. doi: 10.1016/j.jaad.2008.10.014. Epub 2008 Nov 25.
6
Viral infection and iron metabolism.病毒感染与铁代谢
Nat Rev Microbiol. 2008 Jul;6(7):541-52. doi: 10.1038/nrmicro1930.
7
Iron withholding: a defense against disease.铁限制:一种抵御疾病的防御机制。
J Alzheimers Dis. 2008 May;13(4):451-63. doi: 10.3233/jad-2008-13409.
10
Iron chelator research: past, present, and future.铁螯合剂研究:过去、现在与未来。
Curr Med Chem. 2003 Jun;10(12):983-95. doi: 10.2174/0929867033457593.

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