Department of Biology and Program in Medical Sciences, Indiana University, Bloomington, IN 47405, USA.
Oxid Med Cell Longev. 2009 Apr-Jun;2(2):107-9. doi: 10.4161/oxim.2.2.8162.
During the past half century, excessive/misplaced iron has been observed to be a risk factor for an increasing number and diversity of disease conditions. An extensive list of conditions and of the types of iron association were published in early 2008. Within the subsequent year, four additional disorders have been recognized to be enhanced by iron: aging muscle atrophy, viral replication, rosacea and pulmonary alveolar proteinosis. This paper adds new data and emphasis on these disorders as entities associated with increased iron load and toxicity.
在过去的半个世纪中,过量/错位的铁已被观察到是越来越多和多样化的疾病状况的一个风险因素。大量的疾病状况和铁关联类型在 2008 年初被发表。在随后的一年中,又有四种疾病被认为因铁的作用而加重:衰老性肌肉萎缩、病毒复制、酒渣鼻和肺泡蛋白沉积症。本文为这些疾病添加了新的数据和重点,这些疾病是与铁负荷和毒性增加相关的实体。