Shindo K, Matsumoto Y, Sumitomo M, Matsumura M, Okubo T
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Ann Allergy. 1991 May;66(5):405-10.
We measured the amounts of leukotriene C4 and D4 in the arterial blood of asthmatic patients during remission and compared these with the amounts of leukotrienes in the arterial blood of asthmatic patients during acute asthma, which had been reported in our previous study. Leukotriene C4 and D4 was detected in five patients during remission at 50.68 +/- 8.28 and 36.68 +/- 17.31 pg/mL (mean +/- SD), respectively. In five control subjects, the amounts of leukotriene C4 and D4 were 78.22 +/- 34.65 and 55.06 +/- 13.54 pg/mL (mean +/- SD), respectively. As cited in our previous report, the amounts of leukotriene C4 and D4 in arterial blood of asthmatic patients during acute asthma were 523.33 +/- 737.06 and 495 +/- 304.48 pg/mL. Hence, there were no significant differences in the leukotriene C4 and D4 values between asthmatic patients during remission and control subjects, whereas there was a significant difference in the leukotriene D4 values between asthmatic patients during acute asthma and, asthmatic patients during remission or control subjects (P less than .01). In addition, the leukotriene C4 values in asthmatic patients during acute asthma were larger than in asthmatic patients during remission or control subjects without a significant difference. The amounts of leukotriene C4 and D4 in arterial blood of asthmatic patients may reflect the degree of severity of acute asthma.
我们测量了哮喘患者缓解期动脉血中白三烯C4和D4的含量，并将其与我们之前研究中报道的哮喘患者急性发作期动脉血中的白三烯含量进行了比较。在缓解期的5例患者中检测到白三烯C4和D4，分别为50.68±8.28和36.68±17.31 pg/mL（均值±标准差）。在5例对照受试者中，白三烯C4和D4的含量分别为78.22±34.65和55.06±13.54 pg/mL（均值±标准差）。如我们之前的报告所述，哮喘患者急性发作期动脉血中白三烯C4和D4的含量分别为523.33±737.06和495±304.48 pg/mL。因此，缓解期哮喘患者与对照受试者之间白三烯C4和D4值无显著差异，而急性发作期哮喘患者与缓解期哮喘患者或对照受试者之间白三烯D4值存在显著差异（P＜0.01）。此外，急性发作期哮喘患者的白三烯C4值高于缓解期哮喘患者或对照受试者，但无显著差异。哮喘患者动脉血中白三烯C4和D4的含量可能反映急性哮喘的严重程度。
