Shindo K, Miyakawa K, Fukumura M
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Int J Tissue React. 1993;15(5):181-4.
We measured changes in plasma levels of leukotriene B4 (LTB4) during the clinical course of bronchial asthma. Samples of 2 ml of blood were drawn from the femoral artery of 5 patients on two occasions: a) during remission and b) during an attack. LTB4 levels were determined by a combination of high-performance chromatography with radioimmunoassay. In the 5 asthmatic patients, the LTB4 levels (mean +/- S.D.) on the two occasions were respectively 34.2 +/- 8.6 and 118.0 +/- 49.5 pg/ml. In contrast, the mean LTB4 level of 5 control subjects was 23.5 +/- 3.77 pg/ml. LTB4 levels differed significantly between remission and an attack. The corresponding mean PaCO2 values on the two occasions were respectively 37.7 +/- 1.8 and 47.3 +/- 2.2 mmHg. LTB4 showed good correlation with PaCO2. We therefore suggest that leukotriene B4 levels in arterial blood are associated with the severity of asthmatic attacks.
我们在支气管哮喘的临床病程中测量了白三烯B4（LTB4）的血浆水平变化。从5例患者的股动脉抽取2ml血液样本，分两次采集：a）缓解期；b）发作期。LTB4水平通过高效液相色谱与放射免疫测定相结合的方法测定。在这5例哮喘患者中，两次测量的LTB4水平（平均值±标准差）分别为34.2±8.6和118.0±49.5pg/ml。相比之下，5例对照受试者的平均LTB4水平为23.5±3.77pg/ml。缓解期和发作期的LTB4水平差异显著。两次测量对应的平均动脉血二氧化碳分压（PaCO2）值分别为37.7±1.8和47.3±2.2mmHg。LTB4与PaCO2具有良好的相关性。因此，我们认为动脉血中白三烯B4水平与哮喘发作的严重程度相关。
