[谷胱甘肽 S-转移酶 M1、谷胱甘肽 S-转移酶 T1 基因多态性与喉癌和下咽癌易感性]

[Polymorphisms of GSTM1, GSTT1 and susceptibility of laryngeal and hypopharyngeal carcinomas].

作者信息

Li Qin, Wang Lingrong, Chen Yanlin, Du Yinghua, Kong Ping, Li Yufen, Xu Xiaoqun

机构信息

Department of Otorhinolaryngology, Linyi People's Hospital of Shandong, Linyi, 276003, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Dec;23(24):1105-7, 1111.

PMID:20359083

Abstract

OBJECTIVE

To study the relationship between genetic polymorphisms of GSTM1 GSTT1 and the susceptibility of laryngeal and hypopharyngeal carcinomas (LHC).

METHOD

The GSTM1 and GSTT1 genotypes were determined by multiplex PCR analysis in 76 LHC patients and 76 population controls. The association between the genotypes and LHC risk was measured by odds ratios (ORs) and 95% confidence intervals (95% CIs).

RESULT

The frequency of GSTM1 null genotype was 59.2% in the LHC patients and 42.1% in controls (OR=1.935, 95% CI=1.069-3.510), the difference was significant (P<0.01). The frequency of GSTT1 null genotype was 57.9% in the LHC patients and 51.3% in controls. The difference was not significant (P>0.05). In smokers, the risk of the LHC increased in subjects of GSTM1 null genotype (OR=5.545, 95% CI=2.158-13.528).

CONCLUSION

GSTM1 polymorphisms are associated with susceptibility to the LHC. It has the synergistic effects with smoking in the development of the LHC. GSTT1 genotypes might have no association with risk of the LHC in urban Linyi.

摘要

目的

研究谷胱甘肽硫转移酶M1（GSTM1）和谷胱甘肽硫转移酶T1（GSTT1）基因多态性与喉癌和下咽癌（LHC）易感性之间的关系。

方法

采用多重聚合酶链反应分析方法，对76例LHC患者和76名人群对照者进行GSTM1和GSTT1基因分型。通过比值比（OR）和95%置信区间（95%CI）来衡量基因型与LHC风险之间的关联。

结果

LHC患者中GSTM1缺失基因型的频率为59.2%，对照组为42.1%（OR=1.935，95%CI=1.069-3.510），差异有统计学意义（P<0.01）。LHC患者中GSTT1缺失基因型的频率为57.9%，对照组为51.3%，差异无统计学意义（P>0.05）。在吸烟者中，GSTM1缺失基因型个体发生LHC的风险增加（OR=5.545，95%CI=2.158-13.528）。