Organisch-Chemisches Institut, NRW Graduate School of Chemistry, Westfälische Wilhelms Universität, Corrensstrasse 40, 48149 Münster, Germany.
Org Lett. 2010 May 7;12(9):1992-5. doi: 10.1021/ol1004643.
N-heterocyclic carbene catalyzed oxidative amidations of various aldehydes to the corresponding hexafluoroisopropylesters by using the readily available organic oxidant A are described. The hexafluoroisopropylesters prepared in situ are shown to be highly useful active esters for amide bond formation. In addition, oxidative azidation of aldehydes is presented. These mild organocatalytic processes do not use any transition metal.
N-杂环卡宾催化各种醛与易得的有机氧化剂 A 进行氧化氨化反应，生成相应的六氟异丙基酯。所制备的六氟异丙基酯原位显示出作为酰胺键形成的高活性酯。此外，还提出了醛的氧化叠氮化反应。这些温和的有机催化过程不使用任何过渡金属。
