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醛的一锅法氧化酯化和酰胺化反应。

One-pot oxidative esterification and amidation of aldehydes.

作者信息

Ekoue-Kovi Kekeli, Wolf Christian

机构信息

Department of Chemistry, Georgetown University, Washington, DC 20057, USA.

出版信息

Chemistry. 2008;14(21):6302-15. doi: 10.1002/chem.200800353.

Abstract

During recent years, the direct transformation of aldehydes into esters or amides has developed into a vigorous research area and powerful one-pot oxidative esterification and amidation procedures have been reported. Several concepts that are often complementary in substrate scope, functional group tolerance, and reaction outcome have emerged, thus providing a wide range of alternatives to classical ester and amide synthesis via carboxylic acid intermediates.

摘要

近年来,醛直接转化为酯或酰胺已发展成为一个活跃的研究领域,并且已有强有力的一锅法氧化酯化和酰胺化方法的报道。出现了几个在底物范围、官能团耐受性和反应结果方面通常具有互补性的概念,从而为经由羧酸中间体的经典酯和酰胺合成提供了广泛的替代方法。

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