Ekoue-Kovi Kekeli, Wolf Christian
Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
Chemistry. 2008;14(21):6302-15. doi: 10.1002/chem.200800353.
During recent years, the direct transformation of aldehydes into esters or amides has developed into a vigorous research area and powerful one-pot oxidative esterification and amidation procedures have been reported. Several concepts that are often complementary in substrate scope, functional group tolerance, and reaction outcome have emerged, thus providing a wide range of alternatives to classical ester and amide synthesis via carboxylic acid intermediates.
近年来,醛直接转化为酯或酰胺已发展成为一个活跃的研究领域,并且已有强有力的一锅法氧化酯化和酰胺化方法的报道。出现了几个在底物范围、官能团耐受性和反应结果方面通常具有互补性的概念,从而为经由羧酸中间体的经典酯和酰胺合成提供了广泛的替代方法。