Department of Pharmacology, Wah Medical College Wah Cantt, University of Health Sciences, Lahore, Khayaban-e-Jamia Punjab, Lahore, Pakistan.
J Ethnopharmacol. 2010 May 27;129(2):250-3. doi: 10.1016/j.jep.2010.03.017. Epub 2010 Mar 30.
Extracts of Pistacia integerrima galls have been dispensed by Traditional Practitioners of Subcontinent for chest diseases as well as for aches and pains in the body. This study was planned to evaluate the possible analgesic and antiinflammatory effects of Pistacia integerrima extracts.
Analgesia was determined using acetic acid induced abdominal constriction and formalin induced paw licking in mice. Antinociceptive effect was observed by thermally induced algesia in mice.
Pistacia integerrima leaves extracts showed significant response against chemically induced pain (P<0.001) whereas galls extracts had highly significant protection (P<0.0001) in a dose dependent manner. In thermally induced algesia, Pistacia integerrima galls extracts 200 mg/kg (p.o.), showed significant (P<0.05) response but less than pentazocine and diclofenac, positive references. The extracts of Pistacia integerrima 50-200 mg/kg (p.o.) had modest activity against hind paw acute and chronic inflammation induced by formalin (P<0.01).
These results demonstrate that Pistacia integerrima extracts have antinociceptive and analgesic effects and no apparent acute toxicity on oral administration.
印度铁树的叶和瘿一直被次大陆的传统医生用于治疗胸部疾病和身体疼痛。本研究旨在评估印度铁树提取物可能具有的镇痛和抗炎作用。
采用醋酸诱导的小鼠腹部收缩和甲醛诱导的舔足来评估镇痛作用，用热诱导的疼痛来观察其抗伤害作用。
印度铁树叶提取物对化学诱导的疼痛有显著的反应（P<0.001），而瘿提取物具有高度显著的保护作用（P<0.0001），呈剂量依赖性。在热诱导的疼痛中，印度铁树瘿提取物 200mg/kg（po）显示出显著的（P<0.05）反应，但低于阳性对照戊四唑和双氯芬酸。印度铁树提取物 50-200mg/kg（po）对甲醛诱导的后爪急性和慢性炎症具有适度的活性（P<0.01）。
这些结果表明，印度铁树提取物具有镇痛和抗炎作用，口服给药无明显急性毒性。
