哺乳动物睡眠的细胞和化学神经科学。
Cellular and chemical neuroscience of mammalian sleep.
机构信息
Laboratory of Sleep and Cognitive Neuroscience, Departments of Psychiatry, Neurology, and Neuroscience, Boston University School of Medicine, 85 East Newton Street, Suite: M-902, Boston, MA 02118, USA.
出版信息
Sleep Med. 2010 May;11(5):431-40. doi: 10.1016/j.sleep.2010.02.002. Epub 2010 Mar 31.
Abstract
Extraordinary strides have been made toward understanding the complexities and regulatory mechanisms of sleep over the past two decades thanks to the help of rapidly evolving technologies. At its most basic level, mammalian sleep is a restorative process of the brain and body. Beyond its primary restorative purpose, sleep is essential for a number of vital functions. Our primary research interest is to understand the cellular and molecular mechanisms underlying the regulation of sleep and its cognitive functions. Here I will reflect on our own research contributions to 50 years of extraordinary advances in the neurobiology of slow-wave sleep (SWS) and rapid eye movement (REM) sleep regulation. I conclude this review by suggesting some potential future directions to further our understanding of the neurobiology of sleep.
摘要
在过去的二十年中，得益于快速发展的技术的帮助，人们在理解睡眠的复杂性和调节机制方面取得了非凡的进展。从最基本的层面来说，哺乳动物的睡眠是大脑和身体的恢复过程。除了主要的恢复功能外，睡眠对许多重要功能也是必不可少的。我们的主要研究兴趣是了解调节睡眠及其认知功能的细胞和分子机制。在这里，我将回顾我们自己对慢波睡眠（SWS）和快速眼动（REM）睡眠调节的神经生物学 50 年非凡进展的研究贡献。最后，我通过提出一些潜在的未来方向，建议进一步加深我们对睡眠神经生物学的理解。
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