Ramm P, Frost B J
Brain Res. 1986 Feb 12;365(1):112-24. doi: 10.1016/0006-8993(86)90728-6.
[14C]2-deoxyglucose autoradiography was used to show cerebral and regional cerebral metabolism during slow-wave sleep (SWS) and rapid-eye-movement sleep (REM) in the cat. Lower levels of mean cerebral metabolism, reflecting cerebral energy conservation, were associated with SWS. A clear link between REM and mean cerebral metabolism was not observed. At the regional level, SWS was associated with markedly low metabolism in thalamic sensory relays and in cortex. REM was associated with relatively low metabolism in the cerebellum, but with relatively high metabolism in the hippocampus, and in some 'motor' regions including the trigeminal and red nuclei. Thus, SWS was linked to cerebral energy conservation and to particularly low levels of functional activity in cortical and sub-cortical sensory regions. REM was unlike SWS in that: REM did not appear to be strongly linked to cerebral energy conservation; REM was linked to metabolism in fewer brain regions than was SWS; and most REM-linked regions exhibited relatively high levels of metabolism. In addition, while SWS was most clearly associated with functional activity in sensory regions, REM was linked to functional activity in a small number of limbic and motor regions. In sum, SWS and REM are associated with distinctive cerebral metabolic and functional states.
采用[14C]2-脱氧葡萄糖放射自显影技术，来显示猫在慢波睡眠（SWS）和快速眼动睡眠（REM）期间的全脑及局部脑代谢情况。反映脑能量保存的平均脑代谢水平较低，与慢波睡眠有关。未观察到快速眼动睡眠与平均脑代谢之间存在明显联系。在局部水平上，慢波睡眠与丘脑感觉中继核和皮层中明显较低的代谢有关。快速眼动睡眠与小脑相对较低的代谢有关，但与海马体以及包括三叉神经核和红核在内的一些“运动”区域中相对较高的代谢有关。因此，慢波睡眠与脑能量保存以及皮质和皮质下感觉区域中特别低水平的功能活动有关。快速眼动睡眠与慢波睡眠不同之处在于：快速眼动睡眠似乎与脑能量保存没有紧密联系；与慢波睡眠相比，快速眼动睡眠与较少脑区的代谢有关；并且大多数与快速眼动睡眠相关的区域表现出相对较高的代谢水平。此外，虽然慢波睡眠最明显地与感觉区域的功能活动相关，但快速眼动睡眠与少数边缘和运动区域的功能活动有关联。总之，慢波睡眠和快速眼动睡眠与独特的脑代谢和功能状态相关。
