Berg D, Abson K G, Prose N S
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Arch Dermatol. 1991 Jun;127(6):866-70.
Growing awareness of Lyme disease, caused by the tickborne spirochete Borrelia burgdorferi has led to a marked increase in laboratory procedures to help in its diagnosis. Despite the frequent ordering of serologic tests specific for Lyme disease, there remains confusion in the accurate interpretation of these tests. Because of the important cutaneous manifestations of B burgdorferi infection, dermatologists should understand the role of the laboratory in Borrelia-related conditions. This article reviews laboratory techniques available for the diagnosis of Lyme disease. The role of histologic findings and culture, the sensitivity, specificity, and reproducibility of commonly used serologic tests, the effects of disease duration and treatment on serologic results, and the future of laboratory diagnosis are described.
由蜱传播的螺旋体伯氏疏螺旋体引起的莱姆病，其认知度不断提高，这导致用于帮助诊断该病的实验室检测程序显著增加。尽管经常进行针对莱姆病的血清学检测，但在这些检测结果的准确解读方面仍存在困惑。由于伯氏疏螺旋体感染有重要的皮肤表现，皮肤科医生应了解实验室在与疏螺旋体相关疾病中的作用。本文综述了可用于诊断莱姆病的实验室技术。描述了组织学检查结果和培养的作用、常用血清学检测的敏感性、特异性和可重复性、疾病持续时间和治疗对血清学结果的影响以及实验室诊断的未来发展。
