Vogt A
Abteilung Immunologie, Universität Freiburg.
Fortschr Med. 1990 Apr 10;108(10):194-7.
The multiplicity of the clinical appearance of Lyme disease makes it necessary to confirm the diagnosis by detecting the pathogen or specific antibodies. Isolation of the pathogen from infected tissue or body fluids is difficult, so that, to date, only serology is feasible for routine diagnosis. In view of a lack of standardisation of borrelia serology, the clinician must expect false negative, and--even more so--false-positive, results. Future laboratory diagnosis should be markedly improved by nucleic acid hybridisation for the detection of the pathogen, and the use of specific immunodominant antigens for antibody detection.
莱姆病临床表现的多样性使得有必要通过检测病原体或特异性抗体来确诊。从感染组织或体液中分离病原体很困难，因此，迄今为止，常规诊断仅血清学可行。鉴于疏螺旋体血清学缺乏标准化，临床医生必须预料到会出现假阴性结果，更会出现假阳性结果。未来，通过核酸杂交检测病原体以及使用特异性免疫显性抗原检测抗体，实验室诊断应会有显著改善。
