纤毛在平面细胞极性和流动的作用下自我组织。
Cilia self-organize in response to planar cell polarity and flow.
机构信息
Department of Biochemistry & Biophysics, UCSF, San Francisco, CA 94158, USA.
出版信息
Nat Cell Biol. 2010 Apr;12(4):314-5. doi: 10.1038/ncb0410-314.
PMID:20360747
Abstract
Cilia drive fluid flow in development and physiology, but this requires that all cilia in a tissue orient the same way. Earlier studies indicated that both planar cell polarity (PCP) signalling and cilia-generated fluid flows could influence ciliary orientation. We now learn how asymmetric localization of PCP proteins influences the position and orientation of cilia to control the direction of flow.
摘要
纤毛在发育和生理过程中推动液体流动，但这需要组织中的所有纤毛都朝着同一个方向排列。早期研究表明，平面细胞极性（PCP）信号和纤毛产生的流体流动都可以影响纤毛的方向。现在我们了解到 PCP 蛋白的不对称定位如何影响纤毛的位置和方向，从而控制流动的方向。
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