Department of Biochemistry & Biophysics, UCSF, San Francisco, CA 94158, USA.
Nat Cell Biol. 2010 Apr;12(4):314-5. doi: 10.1038/ncb0410-314.
Cilia drive fluid flow in development and physiology, but this requires that all cilia in a tissue orient the same way. Earlier studies indicated that both planar cell polarity (PCP) signalling and cilia-generated fluid flows could influence ciliary orientation. We now learn how asymmetric localization of PCP proteins influences the position and orientation of cilia to control the direction of flow.
纤毛在发育和生理过程中推动液体流动，但这需要组织中的所有纤毛都朝着同一个方向排列。早期研究表明，平面细胞极性（PCP）信号和纤毛产生的流体流动都可以影响纤毛的方向。现在我们了解到 PCP 蛋白的不对称定位如何影响纤毛的位置和方向，从而控制流动的方向。
