Turbitt M L, Patrick R S, Goudie R B, Buchanan W M
J Clin Pathol. 1977 Dec;30(12):1124-8. doi: 10.1136/jcp.30.12.1124.
A retrospective examination in South-west Scotland of formalin-fixed paraffin-embedded liver tissue by an immunoperoxidase technique revealed hepatitis B surface antigen (HBsAg) in eight out of 81 cases (10%) of primary hepatocellular carcinoma (PHC) and in four out of 82 cases (5%) of cirrhosis. No positive staining was found in 112 controls without overt liver disease matched for age and sex. Unlike most previous studies showing an association between HBsAg and PHC, the present investigation was carried out in an area where HBs antigenaemia is infrequent and PHC is an uncommon tumour. While possibly hepatitis infection is an important cause of PHC, the association between HBsAg and PHC could be due merely to activation by the tumour of latent virus B in a previously infected person.
在苏格兰西南部，采用免疫过氧化物酶技术对福尔马林固定石蜡包埋的肝组织进行回顾性检查，结果显示，在81例原发性肝细胞癌（PHC）患者中，有8例（10%）检出乙型肝炎表面抗原（HBsAg）；在82例肝硬化患者中，有4例（5%）检出HBsAg。在112例年龄和性别匹配、无明显肝脏疾病的对照者中未发现阳性染色。与之前大多数显示HBsAg与PHC之间存在关联的研究不同，本研究是在一个HBs抗原血症不常见且PHC是一种罕见肿瘤的地区进行的。虽然肝炎感染可能是PHC的一个重要病因，但HBsAg与PHC之间的关联可能仅仅是由于肿瘤激活了先前感染者体内潜伏的病毒B。
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