Department of Microbiology, Ambrose Alli University, Ekpoma, Nigeria.
Int J Gen Med. 2009 Dec 29;2:171-5. doi: 10.2147/ijgm.s2641.
A four-year prospective study was carried out to determine the incidence and rate of development of resistance by common urinary tract infection (UTI) pathogens to quinolone antimicrobial agents. Results show that there is high intrinsic resistance to the quinolones among strains of Pseudomonas aeruginosa (43.4%), Escherichia coli (26.3%), and Proteus spp. (17.1%). Over four years, rising rates of resistance were observed in P. aeruginosa (14.6% increase), Staphylococcus aureus (9.8%), and E. coli (9.7%). The highest potency was exhibited by ciprofloxacin (91.2%), levofloxacin (89.2%), and moxifloxacin (85.1%), while there were high rates of resistance to nalidixic acid (51.7%) and pefloxacin (29.0%). Coliforms, particularly E. coli (>45%), remain the most prevalent causative agents of UTI while females within the age range of 20-50 years were most vulnerable to UTI.
进行了一项为期四年的前瞻性研究，以确定常见尿路感染（UTI）病原体对喹诺酮类抗菌药物的耐药发生率和发展速度。结果表明，绿脓假单胞菌（43.4%）、大肠杆菌（26.3%）和变形杆菌属（17.1%）对喹诺酮类药物具有很高的固有耐药性。在四年内，铜绿假单胞菌（14.6%的增加）、金黄色葡萄球菌（9.8%）和大肠杆菌（9.7%）的耐药率呈上升趋势。环丙沙星（91.2%）、左氧氟沙星（89.2%）和莫西沙星（85.1%）的抗菌效果最强，而萘啶酸（51.7%）和培氟沙星（29.0%）的耐药率较高。大肠埃希菌（>45%）仍然是 UTI 最常见的病原体，而 20-50 岁的女性最容易受到 UTI 的影响。
