Institute of Cardiovascular Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.
Cell Immunol. 2010;263(1):99-104. doi: 10.1016/j.cellimm.2010.03.004. Epub 2010 Mar 11.
Total saponins of panax ginseng (TSPG) are the major active components in panax ginseng. Dendritic cells (DCs) play an active role in the immunological processes related to atherosclerosis. The purpose of this study was to determine the effect and possible mechanisms of TSPG on the maturation and immune function of DCs. Compared with those untreated, the DCs pre-treated with TSPG and then induced by oxidized-LDL exhibited a significantly lower expression of the maturation-associated markers of CD40, CD86, HLA-DR, and CD1a, together with an increased endocytosic function as well as decreased secretions of cytokine. However, silencing the expression of PPARgamma in DCs, the inhibitory effect of TSPG on the maturation DCs was significantly reduced. In conclusion, TSPG could inhibit the maturation of DCs induced by oxidized-LDL which suggests beneficial effects on atherosclerosis and this effect was partly dependent on the PPARgamma pathway at least.
人参总皂苷（TSPG）是人参中的主要活性成分。树突状细胞（DC）在与动脉粥样硬化相关的免疫过程中发挥积极作用。本研究旨在确定 TSPG 对 DC 成熟和免疫功能的影响及其可能的机制。与未经处理的细胞相比，用 TSPG 预处理然后用氧化型 LDL 诱导的 DC，其成熟相关标志物 CD40、CD86、HLA-DR 和 CD1a 的表达明显降低，同时内吞作用增强，细胞因子分泌减少。然而，沉默 DC 中 PPARγ的表达，TSPG 对成熟 DC 的抑制作用显著降低。总之，TSPG 可抑制氧化型 LDL 诱导的 DC 成熟，这表明对动脉粥样硬化有有益作用，这种作用至少部分依赖于 PPARγ通路。
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