Noonan Vikki L, Greene David J, Brodsky Gilbert, Kabani Sadru P
Department of Pathology, Harvard Vanguard Medical Associates, 133 Brookline Ave., Boston, MA 02215, USA.
Head Neck Pathol. 2010 Jun;4(2):169-73. doi: 10.1007/s12105-010-0175-5. Epub 2010 Apr 3.
The perineurioma is an infrequently encountered benign peripheral nerve sheath tumor composed of a clonal proliferation of perineurial cells. Rare cases of perineurioma have been reported in the oral cavity. An extraneural sclerosing perineurioma arising in the buccal mucosa of a 17-year-old male is presented. Histopathologically, the tumor is composed of a well circumscribed nodular proliferation of spindle cells arranged in a storiform growth pattern, in some areas subtly arranged around vascular channels. The tumor cells reveal positive immunostaining for epithelial membrane antigen (EMA), collagen type IV and vimentin, and negative immunostaining for S-100 protein, consistent with a perineurial origin. To the best of our knowledge, this case represents the first report of an extraneural sclerosing perineurioma involving the oral cavity.
神经束膜瘤是一种罕见的良性周围神经鞘瘤，由神经束膜细胞的克隆性增殖组成。口腔中报道过罕见的神经束膜瘤病例。本文报告了1例发生于17岁男性颊黏膜的神经外硬化性神经束膜瘤。组织病理学上，肿瘤由梭形细胞呈漩涡状生长模式形成边界清楚的结节状增殖构成，在某些区域围绕血管通道呈细微排列。肿瘤细胞上皮膜抗原（EMA）、IV型胶原和波形蛋白免疫染色呈阳性，S-100蛋白免疫染色呈阴性，符合神经束膜起源。据我们所知，该病例是涉及口腔的神经外硬化性神经束膜瘤的首例报道。
