Li Qiong, Li Yong
Department of Nutrition & Food Hygiene, School of Public Health, Peking University, Beijing, China.
Wei Sheng Yan Jiu. 2010 Jan;39(1):123-6.
Considering the multi-etiological characters of neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease, the current pharmacological approaches using drugs oriented towards a single molecular target possess limited ability to modify the course of the diseases. Green tea polyphenols have been reported to possess more than two active neuroprotective-neurorescue moieties that simultaneously manipulate multiple targets involved in neurodegeneration. This review aims to shed light on the multipharmacological neuroprotective activities and the mechanisms of green tea polyphenols on neurodegenerative diseases.
考虑到帕金森病和阿尔茨海默病等神经退行性疾病的多病因特征，目前针对单一分子靶点的药物药理学方法改变疾病进程的能力有限。据报道，绿茶多酚具有两个以上的活性神经保护 - 神经救援部分，可同时作用于神经退行性变涉及的多个靶点。本综述旨在阐明绿茶多酚对神经退行性疾病的多药理学神经保护活性及其机制。
