Department of Environmental Health Science, University of Georgia, Athens, Georgia, USA.
PLoS One. 2012;7(10):e48090. doi: 10.1371/journal.pone.0048090. Epub 2012 Oct 31.
Osteoporosis is a degenerative bone disease predominantly in postmenopausal women. Green tea polyphenols (GTP) and Tai Chi (TC) have been shown to be beneficial on human bone health. This study examined the efficacy of GTP and TC on mitigation of oxidative damage in postmenopausal women with osteopenia.
A 6-month randomized and placebo-controlled clinical trial was conducted in 171 postmenopausal women with osteopenia, who were recruited from Lubbock County, Texas. These participants were treated with placebo, GTP (500 mg daily), placebo + TC (60-minute group exercise, 3 times/week), or GTP (500 mg daily) + TC (60-minute group exercise, 3 times/week), respectively. Their blood and urine samples were collected at the baseline, 1-, 3- and 6-months during intervention for assessing levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative DNA damage biomarker, and concentrations of serum and urine GTP components.
The elevated concentrations of serum and urinary GTP components demonstrated a good adherence for the trial. A significant reduction of urinary 8-OHdG concentrations was found in all three treated groups during 3-month (P<0.001) and 6-month (P<0.001) intervention, as compared to the placebo group. The significant time- and dose-effects on mitigation of the oxidative damage biomarker were also found for GTP, TC, and GTP+TC intervened groups.
Our study demonstrated that GTP and TC interventions were effective strategies of reducing the levels of oxidative stress, a putative mechanism for osteoporosis in postmenopausal women, and more importantly, working in an additive manner, which holds the potential as alternative tools to improve bone health in this population.
ClinicalTrials.gov NCT00625391.
骨质疏松症是一种主要发生在绝经后妇女身上的退行性骨病。绿茶多酚（GTP）和太极拳（TC）已被证明对人类骨骼健康有益。本研究旨在探讨 GTP 和 TC 对改善骨质疏松症患者骨量减少的氧化损伤的疗效。
在德克萨斯州拉伯克县招募了 171 名患有骨质疏松症的绝经后妇女，进行了为期 6 个月的随机、安慰剂对照临床试验。这些参与者分别接受安慰剂、GTP（每天 500 毫克）、安慰剂+TC（60 分钟小组运动，每周 3 次）或 GTP（每天 500 毫克）+TC（60 分钟小组运动，每周 3 次）治疗。在干预期间的基线、1 个月、3 个月和 6 个月，采集他们的血液和尿液样本，以评估 8-羟基-2'-脱氧鸟苷（8-OHdG）的水平，8-OHdG 是一种氧化 DNA 损伤生物标志物，以及血清和尿液 GTP 成分的浓度。
血清和尿液 GTP 成分浓度升高表明试验依从性良好。与安慰剂组相比，所有三组治疗组在 3 个月（P<0.001）和 6 个月（P<0.001）干预期间，尿液 8-OHdG 浓度显著降低。GTP、TC 和 GTP+TC 干预组也发现了对氧化损伤生物标志物缓解的显著时间和剂量效应。
我们的研究表明，GTP 和 TC 干预是降低氧化应激水平的有效策略，氧化应激是绝经后妇女骨质疏松症的一个潜在机制，更重要的是，它们以一种附加的方式发挥作用，这为改善该人群的骨骼健康提供了潜在的替代工具。
ClinicalTrials.gov NCT00625391。
