Mandel Silvia A, Weinreb Orly, Amit Tamar, Youdim Moussa B H
Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel.
Front Biosci (Schol Ed). 2012 Jan 1;4(2):581-98. doi: 10.2741/S286.
Mounting evidence suggests that lifestyle factors, especially nutrition are essential factor for healthy ageing. However, as a result of the increase in life expectance, neurodegenerative diseases like Alzheimer's and Parkinson's (AD and PD, respectively) are becoming an increasing burden, as aging is their main risk factor. Brain aging and neurodegenerative diseases of the elderly are characterized by oxidative damage, dysregulation of redox metals homeostasis and inflammation. Thus, it is not surprising that a large amount of drugs/agents in therapeutic use for these conditions are antioxidants/metal complexing, bioenergetic and anti-inflammatory agents. Natural plant polyphenols (flavonoids and non-flavonoids) are the most abundant antioxidants in the diet and as such, are ideal nutraceuticals for neutralizing stress-induced free radicals and inflammation. Human epidemiological and new animal data suggest that green and black flavonoids named catechins, may help protecting the aging brain and reduce the incidence of dementia, AD and PD. This review will present salient features of the beneficial multi-pharmacological actions of black and green tea polyphenols in aging and neurodegeneration, and speculate on their potential in drug combination to target distinct pathologies as a therapeutic disease modification approach.
越来越多的证据表明，生活方式因素，尤其是营养，是健康衰老的关键因素。然而，由于预期寿命的增加，像阿尔茨海默病和帕金森病（分别为AD和PD）这样的神经退行性疾病正成为日益沉重的负担，因为衰老是其主要风险因素。老年人的大脑衰老和神经退行性疾病的特征是氧化损伤、氧化还原金属稳态失调和炎症。因此，用于这些病症治疗的大量药物/制剂是抗氧化剂/金属络合剂、生物能剂和抗炎剂，这并不奇怪。天然植物多酚（黄酮类和非黄酮类）是饮食中最丰富的抗氧化剂，因此是中和应激诱导的自由基和炎症的理想营养保健品。人类流行病学和新的动物数据表明，名为儿茶素的绿茶和黑茶黄酮类物质可能有助于保护衰老的大脑并降低痴呆、AD和PD的发病率。本综述将介绍黑茶和绿茶多酚在衰老和神经退行性变中的有益多药理学作用的显著特征，并推测它们在药物联合中针对不同病理作为治疗性疾病修饰方法的潜力。
