Fridman W H
Laboratorie d'Immunologie Cellulaire et Clinique, INSERM U255, Institut Curie, Paris, France.
Bull Cancer. 1991;78(2):195-201.
The proliferation and the differentiation of B lymphocytes is under the control of T cell and macrophage produced cytokines which drive resting B cells to the state of antibody-producing plasma cells. Antibodies exert a feedback control of their own production via their interaction with Fc receptor (FcR) bearing cells and the production of Immunoglobulin-Binding Factors (IBF). The fact that some malignant B cells are sensitive to the same factors as normal B lymphocytes opens the possibility to use cytokines as prognostic or therapeutic tools.
B淋巴细胞的增殖和分化受T细胞和巨噬细胞产生的细胞因子控制，这些细胞因子促使静止的B细胞转变为产生抗体的浆细胞状态。抗体通过与携带Fc受体（FcR）的细胞相互作用以及产生免疫球蛋白结合因子（IBF），对自身产生进行反馈控制。一些恶性B细胞对与正常B淋巴细胞相同的因子敏感，这一事实为将细胞因子用作预后或治疗工具提供了可能性。
