胆固醇-磷脂相互作用：来自表面 X 射线散射数据的新见解。
Cholesterol-phospholipid interactions: new insights from surface x-ray scattering data.
机构信息
Center for Molecular Study of Condensed Soft Matter (muCoSM), and Division of Physics, BCPS Department, Illinois Institute of Technology, Chicago, Illinois 60616, USA.
出版信息
Phys Rev Lett. 2010 Mar 12;104(10):108101. doi: 10.1103/PhysRevLett.104.108101. Epub 2010 Mar 8.
Abstract
We report a structural study of cholesterol-DPPC (1,2-dipalmitoyl-sn-glycero-3-phophocholine) monolayers using x-ray reflectivity and grazing incidence x-ray diffraction. Reflectivity reveals that the vertical position of cholesterol relative to phospholipids strongly depends on its mole fraction (chi(CHOL)). Moreover, we find that at a broad range of chi(CHOL) cholesterol and DPPC form alloylike mixed domains of short-range order and the same stoichiometry as that of the film. Based on the data presented, we propose a new model of cholesterol-phospholipid organization in mixed monolayers.
摘要
我们使用 X 射线反射率和掠入射 X 射线衍射研究了胆固醇-DPPC（1,2-二棕榈酰-sn-甘油-3-磷酸胆碱）单层的结构。反射率表明，胆固醇相对于磷脂的垂直位置强烈依赖于其摩尔分数（chi(CHOL)）。此外，我们发现，在宽范围的 chi(CHOL)范围内，胆固醇和 DPPC 形成具有短程有序和与膜相同化学计量比的类似合金的混合域。基于呈现的数据，我们提出了一种混合单层中胆固醇-磷脂组织的新模型。
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