Department of Neurodegenerative Disease, University College London, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Sci Transl Med. 2009 Nov 18;1(7):7ps9. doi: 10.1126/scitranslmed.3000449.
Down syndrome is a complex condition that results from having a third copy of human chromosome 21. People with the syndrome experience problems with learning and memory that affect many aspects of their lives. In this issue of Science Translational Medicine, Salehi et al. report on successful drug treatment of learning deficits in an animal model of Down syndrome. This study highlights the function of the norepinephrine-ergic system in Down syndrome and suggests possible treatment options for people with Down syndrome.
唐氏综合征是一种复杂的疾病，由人类第 21 号染色体出现三份拷贝所致。患有唐氏综合征的人在学习和记忆方面存在问题，这些问题会影响他们生活的多个方面。在本期《科学转化医学》中，Salehi 等人报告了在唐氏综合征动物模型中成功的药物治疗学习障碍的方法。这项研究强调了去甲肾上腺素能系统在唐氏综合征中的作用，并为唐氏综合征患者提供了可能的治疗选择。
